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prednisone in the news

Prednisone causes reader to bruise 

Kane County Chronicle - Oct 08 4:38 AM
Dear Dr. Gott: I am having a lot of trouble with bruising of my skin. I'm told it is from the use of prednisone. I am told it will never go away, the damage is done, and there is nothing that can be done to improve the skin integrity.

Subway Squawkers 
New York Daily News - Oct 09 1:35 AM
October 9

Brief, High-dose Steroid Treatment Offers Extended Relief To Giant Cell Arteritis Patients 
Medical News Today - Oct 08 10:11 AM
A new study offers both hope and a practical treatment option for patients with giant cell arteritis (GCA). Researchers from Emory University and the Mayo Clinic have found that by treating newly diagnosed GCA patients with just three days of a high-dose intravenous steroid, patients relapsed less in the following year and were able to significantly taper off usage of an oral steroid. [click link

SkyePharma Reports Positive Phase III And EU Filing For Lodotra(TM) 
Medical News Today - Oct 05 12:08 AM
SkyePharma PLC (LSE: SKP; Nasdaq: SKYE) today announces positive results of a Phase III clinical trial for Lodotra(TM), a new, modified-release tablet that has been developed in partnership with Nitec Pharma to optimize the efficacy of orally administered low-dose prednisone in Rheumatoid Arthritis (RA). [click link for full article]

predisone

 

 

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- prednisone

Prednisone
Systematic (IUPAC) name
17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl- 7,8,9,10,12,13,14,15,16,17-decahydro-6H- prednizone cyclopenta[a]phenanthrene-3,11-dione
Identifiers
CAS number 53-03-2
ATC prednasone code A07EA03 H02AB07
PubChem 5865
DrugBank APRD00340
Chemical data
Formula C21H26O5
Mol. weight 358.428 g/mol
Pharmacokinetic data
Bioavailability 70%
Metabolism prednisolone prednison (liver)
Half life 1 hour
Excretion Renal
Therapeutic considerations
Pregnancy cat.

A

Legal status

Prescription only

Routes Oral, Nasal, Rectal, Injection, IV

Prednisone is a prednosone synthetic corticosteroid drug which is usually taken orally but can be delivered IM prednsone (intramuscular i.e an injection) and can be used for a large number of prenisone different conditions. It has a pprednisone mainly glucocorticoid effect. Prednisone is a prodrug that is converted by the liver into prednisolone, which is the active prednisona drug and a prednisond steroid.

Contents

  • 1 Uses
  • 2 History
  • 3 Dependency
  • 4 Side presnisone effects
    • 4.1 Major
    • 4.2 Minor
  • 5 External links

Uses

Prednisone is particularly effective as an immunosuppressant and affects virtually all of pretisone the immune system. It can therefore be used in autoimmune pedisone diseases, inflammatory diseases (such prednisone as severe asthma, severe poison ivy, and Crohn's disease), various kidney diseases including nephrotic syndrome, and to prevent and treat prednisone side effects rejection in organ transplantation.

History

Prednisone was invented in the early 1950s when Arthur Nobile at side effects of prednisone Schering demonstrated that the side prednisone withdrawal effects of cortisone such as water retention, high blood pressure and muscle weakness could be removed by oxidisation of side effects of taking prednisone the drug through exposure to microbes. The drug was introduced by Schering prednisone dosage in the mid-1960s.

Dependency

Adrenal suppression occurs if prednisone is taken for feline prednisone longer than 7 days, a condition which means the body is unable to synthesize natural prednisone and weight gain corticosteroids and becomes dependent on the prednisone taken by the patient. For this reason, prednisone prednisone weight gain should not be stopped abruptly if natural prednisone taken for longer than seven days, but needs to be reduced slowly; prednisone and protein cravings this reduction may be over a few days if the course of prednisolone was short, but may take weeks prednisone for dogs or months if the patient has been on long-term treatment. Abrupt withdrawal will lead prednisone without a prescription to an Addisonian crisis, which may be life-threatening.

Side effects

Short-term side effects, as with all prednisone poison ivy glucocorticoids, include high blood glucose levels, allergic reaction to prednisone especially in patients who already have diabetes mellitus or are on other warnings side effects of prednisone medications that increase blood glucose (such as tacrolimus), and mineralocorticoid effects such as fluid retention. Additional short-term side effects include insomnia and alternatives to prednisone rarely mania. Long-term side precautions prednisone effects include Cushing's syndrome, weight gain, osteoporosis, glaucoma, type II diabetes mellitus, and depression upon withdrawal.

Ocular side prednisone dosage anti-inflammatory canine effects of glucocorticoids include glaucoma and cataract formation. While most commonly what is prednisone associated with topical or intraocular administration, these ocular complications may side effects prednisone also occur with oral, intravenous, or even inhaled administration.

Major

  • depression, mania, or other psychiatric symptoms
  • unusual fatigue canine prednisone or weakness
  • blurred vision
  • abdominal pain
  • peptic ulcer
  • infections
  • painful hips or shoulders
  • osteoporosis
  • acne breakouts

Minor

  • weight gain
  • facial swelling
  • nervousness
  • acne
  • rash
  • increased appetite
  • insomnia
  • hyperactivity

External links

  • Prednisone Oral
  • Prednisone Data Sheet
  • Prednisone Bioavailability
  • Link page to external chemical sources.



Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor edit
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, prednisone lawsuits S02B, and S03B)

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