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neuropathy in the news

Depomed Completes Enrollment in Phase II Clinical Trial in Diabetic Peripheral Neuropathy With Gabapentin GR 

RedNova - Oct 05 7:08 AM
Depomed, Inc. (NASDAQ:DEPO) today announced that it has completed enrollment in a Phase II clinical trial to evaluate its Gabapentin GR compound for the treatment of patients with painful diabetic peripheral neuropathy (DPN).

How to give Dad a boost 
USA Today - Oct 08 2:22 PM
My recent series of columns on how lifelong non-exercisers can get themselves moving prompted a great question from one reader: Is it possible to motivate someone else who desperately needs to exercise?

Up Next And Recaps 
CBS News - Oct 08 6:03 PM

Lack of sight is no obstacle for Steph 
Coventry Evening Telegraph - 1 hour, 51 minutes ago
WHEN Steph Cutler lost her eyesight she feared she would never get another job. Now she not only runs a thriving business but has been crowned one of Britain's top ten unsung business heroes by banking giant Barclays.

nueropathy

 

 

- peripheral neuropathy

- neuropathy

Neuropathy
ICD-10 G56. - G63.,
G90.0, nueropathy G99.0
ICD-9 337.0-337.1,
356-357, 377
eMedicine neuropathy topics

Neuropathy, strictly speaking, is any disease that affects neuropthy the nervous system. In common usage, however, neuropathy is short for peripheral neuropathy, meaning neuopathy a disease of the peripheral nervous system, or in other words, a disease affecting one nuropathy or more nerves.

Contents

  • 1 Types
  • 2 Causes
  • 3 Symptoms
  • 4 Treatment neropathy neurapathy of Neuropathic Pain
  • 5 See also
  • 6 Neuropathy related organizations
  • 7 External links

Types

The four major forms of nerve neurpathy damage are polyneuropathy, autonomic neuropathy, neuroapthy mononeuropathy, and mononeuritis multiplex. The most common form is peripheral polyneuropathy, neruopathy which mainly affects the feet and legs.

Causes

Besides diabetes, the common causes of neuropathy are neuropath herpes zoster infection, chronic trauma (such as repetitive motion disorders) or acute trauma (including surgery), and europathy various neurotoxins. Neuropathic neuropathy pain is common in cancer as a direct result of the cancer on peripheral nerves (e.g., compression by a tumor), as peripheral neuropathy a side effect of many chemotherapy drugs, and as a result of diabetic neuropathy electrical injury. In symptoms of peripheral neuropathy many cases no apparent causes can be found, in this case the neuropathy is "idiopathic" meaning no neuropathy in feet cause is found.

Symptoms

Neuropathy often results in numbness, abnormal sensations called dysesthesias and allodynias that neuropathy treatment occur either spontaneously or in reaction treatment for neuropathy to external stimuli, and a characteristic form of pain, called neuropathic pain or neuralgia, that is qualitatively different from the ordinary idiopathic neuropathy nociceptive pain one might experience from stubbing a toe or diabetic neuropathy treatment hitting a finger with a hammer.

Neuropathic pain peripheral neuropathy treatment is usually perceived as a steady burning and/or "pins neuropathy pain treatment and needles" and/or "electric shock" sensations. The difference is due to the diabetes neuropathy fact that "ordinary" pain stimulates only pain nerves, while a neuropathy often results what is neuropathy in the firing of both pain and non-pain (touch, warm, cool) alcoholic neuropathy sensory nerves in the same area, producing signals that the spinal cord and brain do not normally expect to receive.

Treatment of diabetic neuropathy evaluation Neuropathic Pain

Neuropathic pain can be very neuropathy association difficult to treat; sometimes strong opioid analgesics may provide ulnar neuropathy only partial relief. Opoid analgesics are to be considered only as a tertiary treatment. Several classes of causes of peripheral neuropathy medications not normally thought of as analgesics are often effective, alone neuropathy symptoms or in combination with opioids and other treatments. These symptoms of neuropathy include tricyclic antidepressants such as amitriptyline (Elavil®), anticonvulsants such as gabapentin (Neurontin®) and pregabalin (Lyrica®) and serotonin norepinephrine alternative treatment for peripheral neuropathy reuptake periferal neuropathy inhibitors (SSNRI such as duloxetine (Cymbalta®)).

In animal models of neuropathic pain (Bennett & Xie, small fiber neuropathy Pain 33, 87-107 (1988); Seltzer et al., Pain 43, 205-18 (1990); Kim & Chung, Pain 50, 355-63 (1992); Malmberg & Basbaum, Pain treatment peripheral neuropathy 76, 215-22 (1998); Sung et al., Neurosci Lett 246, 117-9 (1998) ; Lee sensory neuropathy et al., Neuroreport 11, 657-61 (2000); Decosterd & Woolf, Pain 87, 149-58 diabetic peripheral neuropathy (2000); Vadakkan et al., J Pain 6, 747-56 optic neuropathy (2005), compounds that only block serotonin alpha lipoic acid and peripheral neuropathy reuptake do not improve neuropathic pain. Similarly, compounds that only neuropathy feet block norepinephrine reuptake also do not improve neuropathic pain. Compounds such as dulexetine, autonomic neuropathy venlafaxine, and milnacipran that block both serotonin reuptake and norepinephrine reuptake do improve neuropathic pain. Antidepressants usually reduce neuropathic pain more quickly neuropathy pain and with peripheral neuropathy from spinal cord injury smaller doses than they relieve depression. Antidepressants therefore seem to work differently on neuropathic pain than on depression, perhaps by activating descending alpha lipoic acid dosage in neuropathy norepinephrinergic and serotonergic pathways in the spinal cord auditory neuropathy that block pain signals from ascending neuropathy evaluation to the brain.

The newer anticonvulsants gabapentin and pregabalin appear to work by blocking calcium anodyne therapy for diabetic neuropathy channels in damaged peripheral neurons. Tricyclic antidepressants may also work on sodium online classes for a degree in peripheral neuropathy channels in peripheral nerves. The anticonvulsants carbamazepine (Tegretol®) and oxcarbazepine (Trileptal®), especially effective on info alpha lipoic acid neuropathy trigeminal neuralgia, are thought to work principally on sodium ischemic optic neuropathy channels.

In general, the antidepressants seem to be most effective on continuous neuropathy autoimmune burning pain, while the anticonvulsants seem to work best on sudden, lancinating, "shock-like" pains that appear to involve large numbers of vitamins and peripheral neuropathy peripheral nerves improperly firing together.

In some forms alpha lipoic acid neuropathy of neuropathy, especially post-herpes neuralgia, the topical application of local anesthetics chronic inflammatory demyelinating poly neuropathy such as lidocaine can provide relief. A transdermal hypothalmic disease with neuropathy patch containing 5% lidocaine is available. Ketamine in a transdermal gel is also frequently effective when the neuropathy is motor neuropathy localized. Neurontin 100mg/g PLO gel is also effective neurontin and peripheral neuropathy for treating peripheral neuropathy, including Carpal Tunnel Syndrome.

In some neuropathic pain syndromes, "crosstalk" occurs between descending sympathetic thyroid neuropathy nerves and ascending sensory nerves. Increases in sympathetic nervous system activity result in an increase of vitamin b12 hiv neuropathy diabetic neuropathy drug trials pain; this is known as sympathetically-mediated pain. Reducing the sympathetic nerve activity in the painful alpha lipoic acid and neuropathy region with local nerve blocks or systemic medications such as clonidine may provide influenza vaccine and neuropathy relief.

The NMDA receptor seems to play a major role in neuropathic pain and in the development of opioid tolerance, neuropathy after root canals and many experiments in both neuropathy chat rooms animals and humans have established that NMDA antagonists such as ketamine and dextromethorphan can treatments for peripheral neuropathy alleviate neuropathic pain and reverse opioid tolerance. Unfortunately, only a few NMDA antagonists are clinically available and vegan diet and neuropathy their use is usually alpha lipoic acid for neuropathy associated with unacceptable side effects.

Several opioids, particularly methadone, have NMDA antagonist activity in addition to femoral neuropathy their μ-opioid agonist properties that seems to make them effective against neuropathic herbal remedies for peripheral neuropathy pain, although this is still the subject of intensive research and clinical is alpha lipoic acid good for neuropathy study. Methadone has this property because it is a racemic mixture; one stereo-isomer physician referral for diabetic neuropathy wisconsin is a μ-opioid agonist; the other is a NMDA antagonist.

In addition to pharmacological poly neuropathy treatment there are several other modalities that help signs of diabetic neuropathy some cases. While lacking double blind trials, these have shown to reduce pain and improve patient alpha lipoic acid and diabetic neuropathy quality of life particularly for chronic neuropathic pain: Interferential Stimulation; alpha lipoic acid neuropathy methylcobalamin Acupuncture; Meditation; Cognitive Therapy; and prescribed exercise.

See also

  • Ulnar Neuropathy
  • Phantom pain
  • Phantom limb

Neuropathy related organizations

  • Special Interest autonomic neuropathy congestive heart failure Group on Neuropathic Painof the International Association for the Study can flu shots cause neuropathy of Pain (IASP)

External links

  • A neuropathic series of articles from critical care neuropathy a neurologist who researches neuropathic pain
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