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Big pharmaceutical firms are finally perking up 

Deseret Morning News - Oct 08 11:22 PM
The pharmaceutical industry has looked wan and sickly in recent years. Loss of patent protection on many important prescription drugs, coupled with a dearth of new drugs coming out of research labs, has caused drug stocks to trail the overall market.

sad
Steinbrenner labels Yanks 'sad failure' 
AP via Yahoo! News - Oct 08 11:59 AM
Yankees owner George Steinbrenner said he was "deeply disappointed" at his team's elimination in the first round of the AL playoffs, calling it a "sad failure."

diabetes symptoms
Dumaguing: Facts about pre-diabetes 
Sun Star - Oct 09 9:38 AM
WHAT is pre-diabetes? Pre-diabetes is a condition where blood sugar levels are higher than normal, but not yet high enough to be diagnosed as diabetes. Pre-diabetes is a key stage in the development of type 2 diabetes.

diabetes
Entires due for third annual race to fight diabetes 
Lahontan Valley News - 10 minutes ago
Banner Churchill Community Hospital is sponsoring the third annual Outrun Diabetes Race in November. The event is an annual fund-raiser for diabetes education scholarships with a 5K competitive run and a 2.5K fitness walk.

digestive system
Readers, Digest a Cure for Many Ills ; HEALTH NOTES 
RedNova - Oct 08 6:14 PM
By SARAH STACEY However good our diet, our bodies can't reap the benefits if our digestive system isn't working efficiently. That's the sensible concept behind the Mayr Cure, a digestion-cleansing plan devised in about 1920 by Dr Franz Xaver Mayr.

diverticulitis
Diverticulitis is no longer a disease of older people --- HealthandAge 
HealthandAge - Oct 05 12:09 AM
Acute diverticulitis is now being seen in much younger patients, according to a new study. Acute diverticulitis is one of the most frequently acute diseases of the colon. One cause is a low-fiber diet.

diaper rash
Chattem to buy J&J, Pfizer brands for $410 million 
Reuters via Yahoo! Asia News - Oct 06 4:51 AM
NEW YORK (Reuters) - Johnson & Johnson and a unit of Pfizer Inc. agreed to sell the U.S. rights to five brands, including Balmex diaper rash treatment, to Chattem Inc. for $410 million to satisfy regulatory requirements, Chattem said on Friday.

doctors
'Waste' of doctors without jobs 
BBC News - 1 hour, 20 minutes ago
Cuts in NHS hospital trusts in the South East mean newly qualified doctors cannot get jobs, the BMA says.

dope
Dope testing done properly, says Dr. Mendis 
Daily News - Oct 08 1:39 PM
DOPING: The Jani Chathurangani Silva dope test hearing will resume at the National Sports Medicine Institute, Mailtland Place this morning.

dream interpretation
U.S. sovereignty at stake, top WND book says 
WorldNetDaily - Oct 09 5:13 PM
School children in Texas are told to say a pledge to the Mexican flag. A coalition of forces works on setting up a "superhighway" network criss-crossing North America. U.S. courts cite international decisions in their interpretation of the nation's constitution.

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Cymbalta

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Cymbalta
The neutrality of this article is disputed.
Please see the discussion cynbalta on the talk page.
Duloxetine
Systematic (IUPAC) name
(+)-(S)-N-methyl-3-(1-naphthyloxy)- 3-(thiophen-2-yl)-propan-1-amine
Identifiers
CAS number 136434-34-9
ATC cymbalt code N06AX21
PubChem 60835
DrugBank APRD00060
Chemical data
Formula C18H19NOS
Mol. weight 297.416 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding >90%
Metabolism Liver, two P450 isozymes, CYP2D6 and CYP1A2.
Half life 8-17 hours
Excretion 70% cymblata in cymbelta urine, 20% in feces
Therapeutic considerations
Pregnancy cat.

C (USA)

Legal status

Prescription only cymmbalta (USA)

Routes Oral

Duloxetine hydrochloride (brand cymballta names: Cymbalta/Yentreve and in Europe known as Xeristar) is a medically used drug that cimbalta primarily targets major depressive disorders (MDD), pain related to diabetic peripheral neuropathy and stress urinary incontinence (SUI). cumbalta Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) cympalta and norepinephrine (NE), possessing comparable affinities in binding to NE- cmybalta and 5-HT transporter sites. Its behavior contrasts to most other dual-reuptake cymbalta inhibitors in that Ki values are nearly 1:1.

Furthermore, duloxetine lacks affinity cymbalta side effects for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of recent news on cymbalta duloxetine in humans, its half-life is reported to be 10 to 15 cymbalta withdrawal hours. Most common side effects in clinical trials were nausea, somnolence, and dry mouth. cymbalta and weight gain In clinical trials weight gain was neutral cymbalta weight gain compared to placebo. Ongoing studies including a 52 week safety and efficacy trial are available.[1] Long-term side-effects seen in these trials did not vary cymbalta 60 mg capsules from the original approval studies.

Duloxetine is approved by the FDA for the treatment of diabetic neuropathy. Approved dosages for treatment of diabetic peripheral cymbalta withdrawl neuropathic pain are 60 mg and 120 mg once daily.

When used cymbalta duloxetine fibromyalgia in women for the cymbalta message board treatment of depression, the approved dosage is 40 mg to 60 mg once daily. Duloxetine is available in cymbalta and weight loss capsules of 20 mg, 30 mg, and 60 mg.

Duloxetine is also being used to treat pain cymbalta side affects symptoms in patients with fibromyalgia.

References

  1. ^ www.lillytrials.com

External links

  • Manufacturer website
  • Duloxetine and Duloxetine (Systemic) - medlineplus.org
  • Prescribing Guide
  • FDA Alert for Healthcare Professionals
  • FDA Patient Information cymbalta and neck spasms Sheet



Antidepressants (ATC N06A) edit
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Reversible inhibitor of monoamine oxidase A (RIMA) Brofaromine, Moclobemide
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Norepinephrine-dopamine reuptake inhibitors Bupropion
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Noradrenergic and specific serotonergic add cymbalta antidepressant (NaSSA) Mirtazapine
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- recent news on cymbalta

Big pharmaceutical firms are finally perking up 

Deseret Morning News - Oct 08 11:22 PM
The pharmaceutical industry has looked wan and sickly in recent years. Loss of patent protection on many important prescription drugs, coupled with a dearth of new drugs coming out of research labs, has caused drug stocks to trail the overall market.

Making medicine with integrity 
CNN Money - Oct 02 6:22 AM
Fortune interviews Deirdre Connelly, President, Lilly USA Eli Lilly:

Healthcare: Tjugum Takes WS UK Deputy Health MD Role 
RedNova - Sep 30 12:08 AM
Weber Shandwick has promoted director Brian Tjugum to deputy MD of its UK health practice. Tjugum joined 12 months ago from Ogilvy PR Worldwide and takes a position most recently occupied by Lucie Harper, who was promoted to UK health MD this spring (PRWeek, 24 March).

Fitch Affirms Eli Lilly & Co.'s Ratings 
FinanzNachrichten - Sep 19 8:19 AM
Fitch Ratings has affirmed Eli Lilly ( Nachrichten / Aktienkurs ) and Co.'s (Lilly) Issuer Default Rating (IDR), bank loan, and senior unsecured debt ratings of 'AA' and commercial paper rating of 'F1+'. The Outlook remains Stable.