|Systematic (IUPAC) name
|methyl cocane 3-benzoyloxy-8-methyl-8-azabicyclo coccaine [3.2.1]octane-4-carboxylate
||N01BC01 R02AD03, S01HA01, cocanie S02DA02
|Melt. cociane point
|Solubility in water
||1800 mg/mL cacaine (20°C)
||1 cocine hour
||Renal (benzoylecgonine and ecgonine methyl ester)
Schedule I(CA) Class coacine A(UK) Schedule II(US)
||Topical, cocainne Oral, Insufflation, IV, PO
- This article is about the drug cocaine. cocainr For the song by J.J. Cale (later covered by Eric Clapton), cocaime see Cocaine (song).
Cocaine is a crystalline tropane alkaloid that is obtained from the cocaie leaves of the coca plant. It is a stimulant of the central nervous cocaone system and an appetite suppressant, creating what has been described as a euphoric cocan sense of happiness and increased energy. Though cockaine most often used recreationally for this effect, cocaine is also a coke topical anesthetic used in eye, throat, and nose surgery. Cocaine can be psychologically addictive, and its possession, cultivation, cocaine and distribution is crack cocaine illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of eric clapton cocaine the world. The name comes from the name of the coca plant plus the alkaloid suffix -ine.
The stimulating qualities cocaine blues of the coca leaf were known to the ancient peoples of Peru and other Pre-Columbian cocaine addiction South American societies. cocaine energy drink In modern Western countries, cocaine has been a feature of the counterculture cocaine effects for well-over a century; there is a long-list of prominent intellectuals, cutting cocaine with procaine artists, and musicians who have used the drug — names ranging from Sir crack cocaine recipe Arthur Conan Doyle and Sigmund Freud to United States President Ulysses S. cocaine eric clapton Grant. For many decades cocaine was a key ingredient in Coca-Cola. Today, although illegal in virtually all johnny cash cocaine blues countries, cocaine remains popular in a wide variety of social and personal cocaine mp3 settings.
- 1 History
- 1.1 The liquid cocaine coca leaf
- 1.2 Isolation
- 1.3 Medicalization
- 1.4 Popularization
- 1.5 Prohibition
- 1.6 Modern effects of cocaine usage
- 2 Pharmacology
- 2.1 Appearance
- 2.2 Forms how long does cocaine stay in your system facts about cocaine of cocaine
- 2.2.1 Cocaine sulfate
- 2.2.2 Freebase
- 2.2.3 Crack ways to make crack cocaine cocaine
- 2.3 Modes of administration
- 2.3.1 Chewed/eaten
- 2.3.2 Insufflation
- 2.3.3 Injected
- 2.3.4 Smoked
- 2.3.5 Oral
- 2.4 Mechanism cocaine made cocaine cutting agents of cocaine drink action
- 2.5 Metabolism how to make crack cocaine and excretion
- 2.6 Effects and health issues
- 2.6.1 Acute
- 2.6.2 Chronic
- 2.7 Cocaine how to make cocaine as a local cocaine induced depression anesthetic
- 3 Cocaine trade
- 3.1 Production
- 3.2 Trafficking and distribution
- 3.2.1 "Black long term effects of cocaine use cocaine"
- 4 Addiction
- 4.1 Treatment
- 4.1.1 GVG
- 4.1.2 GBR cutting cocaine 12909
- 4.1.3 Venlafaxine
- 4.1.4 Coca how to cut cocaine tea
- 5 Legal status
- 6 Usage
- 6.1 In cocaine symptoms the cocaine dealer United States
- 6.1.1 Overall usage
- 6.1.2 Usage among youth
- 6.1.3 Availability
- 7 References
- 8 See home made cocaine cocaine plant also
- 9 Further reading
- 10 External links
The coca leaf
South American indigenous kate moss cocaine peoples have chewed the coca leaf (Erythroxylum coca), a plant that contains vital nutrients as well as numerous alkaloids, including ancient cocaine use cocaine. The leaf was, and symptoms of cocaine use is, chewed almost universally by some indigenous communities—ancient Peruvian mummies have buy cocaine online been found with the remains of coca leaves, and pottery from cocaine abuse the time period depicts humans whose cheeks are bulged with the presence of something on which they are cocaine overdose chewing. However, it should be noted that there eric clapton - cocaine is no evidence that its habitual use has ever led to any cocaine paraphernalia of the negative consequences generally associated with habitual cocaine use today. There is also cocaine withdrawal symptoms evidence that these side effects of cocaine cultures used a mixture of coca leaves and saliva as an anesthetic snorting cocaine for the performance of trepanation.
The coca plant, Erythroxylum coca
When the Spaniards colonized South America, they at first ignored aboriginal claims that the leaf gave cocaine pictures them strength and energy, and declared the practice of chewing it the work cocaine seizures by boat in spain of the Devil. But after cocaine abstinence discovering that these claims were true, they legalized and taxed the leaf, taking cocaine addict recovery stories 10 percent off the value of each crop. These taxes were for a pictures of cocaine time the main source of support for rerock cocaine the Roman Catholic Church in the region. In 1569, Nicholas Monardes described cocaine and toupees the practice of the natives of chewing a mixture of tobacco and coca leaves to induce "great contentment":
||[...when they wished to] make themselves drunk and [...] out of judgment [they injecting cocaine chewed a mixture of tobacco and coca leaves which ...] cocaine blues johnny cash make them go as they were out of their wittes [...]
In 1609, Padre Blas Valera wrote:
||Coca protects the eric clapton cocaine mp3 body from many ailments, and our doctors use it in powdered form to i love the cocaine reduce the cocaine detection times swelling of wounds, to strengthen broken bones, to expel cold from the body or prevent it cocaine purity test from entering, and to cure rotten wounds or how to cook cocaine sores that are full of maggots. And if it does zoloft and cocaine so much for outward ailments, will not its singular virtue have even greater effect in the entrails of those who eat cocaine intervention drug abuse rehabilitation it?
Although the stimulant and hunger-suppressant properties of coca had been known for many centuries, cocaine cowgirl the isolation of the cocaine alkaloid was not achieved until 1855. Many scientists had attempted to isolate cocaine, cocaine recovery stories but none had been successful for two reasons: the cocaine stories knowledge of chemistry required was insufficient at cocaine addicts the time, worsened because coca does not grow in Europe and ruins easily during travel.
The cocaine alkaloid was first isolated by the cocaine systemic half-life German chemist Friedrich Gaedcke in 1855. Gaedcke named the alkaloid cocaine use “erythroxyline,” and published a description in cocaine users the journal Archives de Pharmacie.
In 1856, Friedrich Wöhler asked Dr. Carl Scherzer, a scientist aboard the Novara (an Austrian signs of cocaine use frigate sent by Emperor Franz Joseph to circle the globe), to clapton cocaine bring him a large amount of coca leaves from South America. cocaine detection In 1859, the ship finished its travels cocaine in a can and Wöhler received a trunk full of coca. Wöhler passed on the leaves cocaine metabolites to Albert Niemann, a Ph.D. student at the University of Göttingen in Germany, who then developed an improved long term effects of cocaine purification process.
Niemann described every step he took pictures of crack cocaine to isolate cocaine in his dissertation signs of cocaine addiction titled Über eine neue organische Base in den Cocablättern (On a New Organic Base in the Coca Leaves), which was published brain changes after quitting cocaine in 1860—it earned him his Ph.D. and is now in the British Library. He cocaine recipes wrote of the alkaloid's “colourless transparent history of cocaine prisms” and said that, “Its solutions have how long does cocaine stay in system an alkaline reaction, a bitter taste, promote the flow of saliva and leave what are the cultural uses for cocaine a peculiar numbness, followed by a sense of cold when applied to the tongue.” Niemann named what are the medical uses for cocaine the alkaloid “cocaine”—as with other alkaloids its name carried the “-ine” suffix (from Latin what is cocaine -ina).
With the discovery anxiety cocaine and depression of this new alkaloid, Western medicine was quick to jump upon and exploit the possible uses bibliography of cocaine of this plant.
In 1879, Vassili von Anrep, of the University of Würzburg, devised an experiment to demonstrate buy cocaine the analgesic properties of the newly-discovered alkaloid. He prepared cocaine mood and feeling abstinence changes two separate jars, one containing a cocaine-salt solution, with the other containing merely cocaine use signs symptoms salt water. He then submerged a frog's legs into the two jars, one leg in cocaine withdrawal the treatment and one in george jung cocaine the control solution, and proceeded to stimulate the legs in several different ways. The leg that had been immersed in the price of cocaine cocaine solution reacted very differently than the leg that had been immersed pure cocaine in salt water.
Carl Koller (a cocaine coca cola close associate of Sigmund Freud, who would write about cocaine later) experimented with cocaine cocaine cut for ophthalmic usage. In an infamous experiment in 1884, cocaine psychosis he experimented upon himself by applying a cocaine solution to his own eye and then pricking cocaine purity it with pins. His findings were presented to the Heidelberg Ophthalmological cook crack cocaine in microwave Society. Also in 1884, Jellinek demonstrated eric clapton cocaine live the effects of cocaine as a respiratory system anesthetic. In 1885, modafanil and topiramate therapy with cocaine addiction William Halsted demonstrated nerve-block anesthesia, and James Corning demonstrated peridural anesthesia. 1898 saw ways to cook crack cocaine Heinrich Quincke use cocaine for antabuse cocaine reaction spinal anesthesia.
In 1859, an Italian doctor, Paolo Mantegazza returned from Peru, where he had witnessed firsthand the use of coca by cocaine blues cash the natives. He proceeded to experiment on himself and upon his return cocaine detox to Milan he wrote a paper cocaine drug paraphernalia in which he described the effects. In this paper he declared coca and cocaine (at the time cocaine prices they were assumed to be the same) depression recovery stories after quitting cocaine as being useful medicinally, in the treatment of “a furred tongue in the how to detox cocaine morning, flatulence, [and] whitening of the teeth.”
Pope Leo XIII purportedly carried a hipflask of Vin yakooza cocaine Mariani with him, and awarded a Vatican gold medal to Angelo Mariani.
A chemist named Angelo Mariani who read Mantegazza’s anxiety cocaine depression paper became immediately intrigued with coca and its cocaine accessories economic potential. In 1863, Mariani started marketing a wine called directions to make cocaine Vin Mariani, which had been treated with coca leaves. The general anxiety disorder and cocaine addiction and therapy ethanol in wine acted as a solvent and extracted the how many hours does cocaine stay in your system cocaine from the coca leaves, altering the drink’s effect. It contained 6 mg cocaine per ounce of how to sell cocaine wine, but Vin Mariani, which was to be exported, contained 7.2 mg per ounce overcoming cocaine induced depression to compete with the higher cocaine content of similar drinks in the United States. A pablo escobar cocaine life “pinch of coca leaves” was included in John Styth Pemberton's original 1886 recipe personality changes after quitting cocaine for Coca-Cola, purchase cocaine online though the company began using decocainized leaves in 1906 when the Pure Food and Drug Act was passed. purify cocaine The only known measure of the amount scared of the future life after quitting cocaine of cocaine in Coca-Cola was determined in 1902 as being signs and symptoms of crack cocaine use as little as 1/400 of a grain (0.2 mg) per ounce of syrup (6 ppm)
. The actual amount of cocaine that Coca-Cola contained cocaine chemistry during the first twenty years of its production is practically impossible to cocaine death statistics determine.
In 1879 cocaine eyes cocaine began to be used to treat morphine addiction. Cocaine was introduced into clinical use as a local anaesthetic cocaine induced depression recovery stories in Germany in 1884, about the same time as Sigmund Freud cocaine induced mental health problems published his work Über Coca, in which he wrote cocaine information that cocaine causes:
||...exhilaration and lasting euphoria, which in no way differs from the normal euphoria of facts on cocaine the healthy person...You perceive an increase of self-control and possess more vitality and capacity for work....In poems about cocaine other words, you are purifying crack cocaine simply normal, and it is soon hard to believe you are under the influence of any drug....Long intensive physical work is remove impurities from cocaine performed without any fatigue...This result is enjoyed without testing cocaine any of the unpleasant after-effects that follow exhilaration brought about by alcohol....Absolutely no what to expect after quitting cocaine craving for the further use of cocaine appears 8 ball of cocaine after the first, or even after repeated taking of cocaine brain the drug...
cocaine in your system
Cocaine, the fast-acting cocaine info anesthetic.
In 1885 the U.S. manufacturer Parke-Davis sold cocaine in various forms, including cigarettes, powder, and even a cocaine manufacturing cocaine mixture that could be injected directly into the cocaine production user’s veins with the included needle. The company promised that its cocaine products would cocaine rehab “supply the place of food, make the coward brave, the silent eloquent and ... deer cocaine render the sufferer insensitive to pain.”
By the late Victorian era cocaine use had appeared disparity in sentencing crack cocaine versus powder as a vice in dj cocaine literature; for example, Arthur Conan Doyle’s fictional Sherlock Holmes injects a "seven-percent solution" of the drug in how cocaine is made The Sign of Four.
In 1909, Ernest Shackleton took “Forced March” brand cocaine tablets to Antarctica, buckcherry cocaine as did Captain Scott a year buy cocaine hcl later on his ill-fated journey to the South Pole. Even as late as 1938, the Larousse Gastronomique was cocaine cale published carrying a recipe for “cocaine pudding”.
By the turn of the twentieth century, the addictive properties cocaine depression of cocaine had become clear to many, and the problem of cocaine abuse began to cocaine facts capture public attention in the United States. The dangers of cocaine abuse became part cocaine glaucoma of a moral panic that cocaine heart was tied to the dominant racial and social anxieties of the day. In 1903, the American Journal of cocaine in system Pharmacy stressed that most cocaine abusers were “bohemians, gamblers, cocaine j.j. cale high- and low-class prostitutes, night porters, bell boys, burglars, racketeers, pimps, and casual laborers.” In 1914, cocaine necklace Dr. Christopher cocaine treatments Koch of Pennsylvania’s State Pharmacy Board made the racial innuendo explicit, testifying that, “Most of the crack cocaine online attacks upon the white women of the deputies find cocaine in car trunk b section an article South are the direct result of a cocaine-crazed Negro brain.” Mass media created an johnny cash cocaine epidemic of cocaine use among African Americans in the Southern United States to kilos of cocaine play upon racial prejudices of the era, though there is little evidence that such morphine cocaine an epidemic actually took place. In the same year, the Harrison Narcotics Tax Act outlawed the pictures of cocaine users use of cocaine in the United States. This law incorrectly referred to cocaine santa marta cocaine as a narcotic, and the misclassification passed into popular culture. As cocaine blues tab stated above, cocaine is a stimulant, not a narcotic.
In many countries, cocaine eric cocaine is a popular recreational drug. In the United States, the development of "crack" cocaine introduced the substance to a generally cocaine induced anxiety poorer inner-city market. Use of cocaine propaganda the powder form has stayed relatively constant, experiencing a new height of use during the late 1990's, however, use cocaine treatment has dropped somewhat from the early 2000's giving way to cocaine versus crack MDMA which has increased in popularity. Cocaine has become cooking powder cocaine much more popular in the last few years in the UK.
Cocaine use is eric clapton cocaine lyrics prevalent across all socioeconomic strata, including age, demographics, economic, social, political, religious, and livelihood. Cocaine in freebase cocaine its various forms comes in second only to cannabis how long crack cocaine stays in your system as the most popular illegal recreational drug in the United States, and johnny cash - cocaine blues is number one in street value sold each liquid cocaine recipe year.
The estimated medical cocaine U.S. cocaine market exceeded $35 billion in street value for the year 2003, passing a cocaine drug test exceeding revenues by corporations such as AT&T and Starbucks
. There after quitting cocaine is a tremendous demand for cocaine in the U.S. alister crowley cocaine market, particularly among those who are making incomes affording luxury spending, such as single adults and various professionals. Cocaine’s cocaine addict depression discovery stories status as a club drug shows its immense popularity among cocaine addict depression recovery stories the “party crowd.” Cocaine’s high revenues may be due to the drug’s psychologically cocaine addiction rehab addictive nature, which makes the cessation of use very difficult.
In 1995 the World Health cocaine additives Organization (WHO) and the United Nations Interregional Crime and Justice Research Institute (UNICRI) announced in a cocaine and dopamine press release the publication of the results cocaine cutting of the largest global study on cocaine use ever undertaken. However, a decision in the cocaine pics World Health Assembly banned the publication cocaine quality test of the study. In the sixth meeting of the B committee cocaine rocks the US representative threatened that "If WHO activities relating to drugs failed to reinforce proven drug cocaine short term memory reversible control approaches, funds for the cocaine spoon relevant programmes should be curtailed". This led to the decision to discontinue publication. A part of the study has been recuperated. Available cocaine synthesis are cocaine use symptoms profiles of cocaine use in 20 countries. Some of the findings were that "Generally cocaine users consume a range of other drugs cocaine withdrawl as well. There depression due to cocaine abuse appears to be very little 'pure' cocaine use. Overall, fewer people liquid cocaine drink in participating countries have used cocaine than have used alcohol, tobacco or cannabis. Also, in my name is cocaine most countries, cocaine is not the drug associated with neurons and how cocaine works the greatest problems.", "There is a complex relationship between cocaine use and crime, particularly theft and violence.", "In most participating countries, a two months after quitting cocaine minority of people start using cocaine or related products, use casually for antibiotics that test positive as cocaine a short or long period, and suffer little average cost of cocaine or no negative consequences, even after years of use. This suggests black cocaine it is possible to reduce, if not entirely eliminate, harmful cocaine use."
A problem with bo bice cocaine arrest warrant illegal cocaine use, especially in bush cocaine the higher volumes used to combat fatigue (rather than increase changes after quitting cocaine euphoria) by long-term users is trauma caused by the compounds used in adulteration. check cocaine purity Cutting or "stamping on" the drug is commonplace, using compounds which simulate ingestion effects, such as novocaine producing temporary cocaine - jj cale anasthaesia, ephedrine producing an increased heart rate, or more dangerously, cocaine addiction detection strong toxins to produce vasodilatory effects. For example a nosebleed is foolishly regarded by heavy users cocaine and alcohol as a sign of purity. The normal adulterants for profit are inactive sugars, cocaine and autism usually mannitol, creatine or glucose, so introducing active cocaine bleach purity test adulterants gives the illusion of purity. Cocaine trading carries large cocaine clapton penalties in most jurisdictions, so user deception about purity and cocaine cowboys consequent high profits for dealers are the norm.
A pile of Cocaine cocaine handbook hydrochloride
Cocaine in its purest form is a white, pearly product. The slang term cocaine in the 80's for fishscale cocaine is derived from this "pearly" appearance, because it resembles the different colors and shine of a cocaine live fish scale cocaine usage (zoology). Cocaine appearing in powder form is a salt, typically cocaine hydrochloride (CAS 53-21-4). Black market cocaine is frequently cocaine use during pregnancy adulterated or “cut” with various cocaine yakooza powdery fillers to increase its weight; the substances most commonly used in this process are baking soda; sugars, such cooking cocaine as lactose, dextrose, inositol, and mannitol; and local anesthetics, such as lidocaine crack and cocaine or benzocaine, which mimic or add to cocaine's numbing effect on mucous membranes. Cocaine may also be developmental psychology and cocaine addiction "cut" with other stimulants such as methamphetamine. Adulterated cocaine how is cocaine sold is often a white, off-white or pinkish powder. Contrary how to freebase cocaine to popular belief, Novacaine (procaine) and benzocaine how to hide cocaine are not very closely chemically-related to cocaine, although they do share a common benzoic acid molecule as well as similar nerve-anesthesia how to inject cocaine properties. These chemicals will not cause a false-positive for cocaine in drug-tests.
The color how to sell cocaine at college of “crack” cocaine life after quitting cocaine depends upon several factors including the origin of the cocaine used, the method of preparation – with ammonia make cocaine fast or sodium bicarbonate – and the presence of impurities, but will generally range penalty for cocaine possession in louisiana from white to a yellowish creme to a light brown. Its texture will personal stories of cocaine induced disorders also depend on the personality changes after cocaine abstinence adulterants, origin and processing of the powdered cocaine, and the method of converting the base; but will process of emotional change after quitting cocaine range from a crumbly texture, sometimes prozac and cocaine addiction extremely oily, to a hard, almost crystalline nature.
Forms of cocaine
Cocaine sulfate purity of cocaine is produced by macerating coca leaves along with water that has been acidulated with sulfuric acid, street pricing cocaine or a naphtha-based solvent, like kerosene or benzene. This is often accomplished by toddler death cocaine putting the ingredients into a vat and stamping on it, in a manner urine drug screen detection times for cocaine similar to the traditional method for crushing grapes. After videos of injecting cocaine the cocaine is extracted, the water is evaporated to yield a pasty mass of what are the effects of crack cocaine on hiv positive impure cocaine sulfate.
The sulfate itself is an intermediate step 8 ball cocaine to producing cocaine hydrochloride. In South best way to smoke cocaine America, it is commonly smoked along with tobacco, and is known as buy cocaine powder pasta, basuco, basa, pitillo or simply paste. It is also gaining popularity as a cheap drug (.30-.70 U.S. cents per cocaine and viagra "hit" or dose) in Argentina.
As the name implies, “freebase” is the base form of cocaine, cocaine depression message boards as opposed to the salt form of cocaine hydrochloride. Whereas cocaine hydrochloride is cocaine eric clapton mp3 extremely soluble in water, cocaine base is insoluble in water cocaine induced depression and anxiety and is therefore not suitable for drinking or cocaine mix snorting. Cocaine hydrochloride is not well-suited for smoking because the temperature at which it vaporizes is very high, and cocaine negative effects close to the temperature at which it burns; however, cocaine base vaporizes at a low temperature, cocaine plant growing which makes it suitable for inhalation.
Smoking freebase is preferred cocaine price by many users because the cocaine is absorbed immediately into cocaine song blood via the lungs, where it reaches the brain in about five seconds. cocaine test The rush is much more intense cocaine vaccine available than sniffing the same amount of cocaine nasally, but the effects do not last as long. The peak connecticut cocaine possession laws of the freebase rush is over almost as soon crack cocaine and seratonin production as the user exhales the vapor, but the high typically lasts 5–10 minutes afterward. What makes freebasing particularly dangerous is depression cocaine recovery stories that users typically don't wait that long for their next el pais cocaine smuggling hit and future fear after quitting cocaine will continue to smoke freebase until none is left. These effects are similar to those that can be achieved by injecting health effects of cocaine or “slamming” cocaine hydrochloride, but without the risks associated with how is cocaine made intravenous drug use (though there are other how long cocaine stays in the body serious risks associated with smoking freebase).
Freebase cocaine is produced by first dissolving cocaine how to make cocaine from household items hydrochloride in water. Once dissolved in water, cocaine hydrochloride (Coc HCl) dissociates into protonated cocaine ion (Coc-H+) and j j cale cocaine chloride ion (Cl–). Any solids that remain in the legalization of cocaine solution are not cocaine (they are part of the cut) and are removed by filtering. A base, typically ma and mdma and ketamine and cocaine and cannabis ammonia (NH3), is added to the solution. managing the patient with a cocaine overdose The following net chemical reaction takes place:
Coc-H+Cl– + NH3 → Coc + NH4Cl
As freebase cocaine (Coc) is insoluble in water, it mexican tequila cocaine precipitates and the solution becomes cloudy. To recover the microwave crack cocaine freebase, a nonpolar solvent like diethyl ether is added to the solution: Because freebase is highly soluble in ether, a online shops selling cocaine snorting paraphenlia vigorous shaking of the mixture results in the freebase psychological addiction to crack cocaine being dissolved in the ether. As ether is insoluble scared of life after quitting cocaine in water, it can be siphoned off. The ether is then evaporated, leaving behind side effect cocaine the cocaine base.
Handling diethyl snorted cocaine ether is dangerous because ether is extremely flammable, its vapors are heavier than air and can “creep” from an open bottle, and in touching cocaine and failing drug test the presence of ways to use cocaine oxygen it can form peroxides, which can spontaneously combust. Demonstrative of the dangers of what goes on after quitting cocaine the practice, the famous comedian Richard Pryor used to perform a well known skit in which he poked fun at what is an 8 ball of cocaine himself over a 1980 incident in which he caused cocaine + methods of use an explosion and set himself on cocaine abuse intervention fire while attempting to smoke “freebase”, presumably while still wet with ether.
A pile cocaine and venezuala of crack cocaine ‘rocks’.
Due to the dangers of using ether to produce pure freebase cocaine, cocaine producers began to omit cocaine blues lyrics the step of removing the freebase cocaine precipitate from the ammonia cocaine container mixture. Typically, filtration processes are also omitted. The end result of this process cocaine cooking is that the cut, cocaine depression and anxiety after quitting in addition to the ammonium salt (NH4Cl), remains in the freebase cocaine after the mixture is evaporated. The “rock” cocaine detection time that is thus formed also contains a small amount of cocaine experiences water. Sodium bicarbonate is also preferred in preparing cocaine in drug test the freebase, for when commonly "cooked" the ratio is 50/50 to 40/60 percent cocaine/bicarbonate. cocaine induced depression, lost confused, indecisiveness This acts as a filler which extends the overall cocaine induced disorders after abstinence profitability of illicit sales. Crack cocaine may be reprocessed in small quantities with water (users refer cocaine investigation in springfield il to the resultant product as "cookback"). This removes the residual bicarbonate, and any adulterants cocaine ship or cuts that have been used in the previous handling of the cocaine and leaves cocaine smuggling a relatively pure, anhydrous cocaine base.
When the rock is heated, this water boils, cocaine substitute making a crackling sound (hence the onomatopoeic “crack”). color is pure cocaine Baking soda is now most often used as a consequences of crack cocaine addiction base rather than ammonia for reasons of lowered stench and toxicity; crack cocaine withdrawl however, any weak base can be used to make crack cocaine. dealing with cocaine induced fear and depression Strong bases, such as sodium hydroxide, tend to hydrolyze some of the cocaine into non-psychoactive ecgonine.
The net reaction when dillinger cocaine in my brain using baking soda (also called drying cocaine sodium bicarbonate, with a chemical formula of NaHCO3) is:
Coc-H+Cl– + NaHCO3 → Coc + H2O + CO2 + NaCl
Crack is unique frued and cocaine because it offers a strong cocaine experience in small, easily affordable packages. In the United States, crack cocaine is often sold how long cocaine stays in system how long cocaine stays in the system in small, inexpensive dosage units frequently known as “nickels”, “nickel rocks”, or "bumps" how long does cocaine stay in the bloodstream (referring to the price of $5.00), and also “dimes”, “dime rocks”, or "boulders" how long does it take for cocaine to leave your system and sometimes as “twenties”, “solids", "slabs" and “forties.” The quantity provided by such a purchase how t cook crack cocaine varies depending upon many factors, such as local johnny cash lyrics cocaine blues availability, which is affected by geographic location. A twenty may yield a quarter gram or half gram on average, yielding 30 minutes legal cocaine to an hour of effect if hits are taken life stories of recovering cocaine addicts with depression every few minutes. After the $20 or $40 mark, crack and powder microwave crack cocaine recipe cocaine are sold in grams new cocaine energy drink or fractions of ounces. Many inner-city addicts with a regular dealer will “work a corner,” taking new jersey cocaine possession penalties money from anyone who wants crack, making a buy from the dealer, people on cocaine then delivering part of the product while keeping some for themselves. This term can also be used for pg/mg chronic cocaine use the dealer themselves, as that is the corner that picture of cocaine one dealer might work for procaine sold as cocaine himself, and this contributes to gang and drug releated shootings.
At the intermediate level, crack cocaine is purifying cocaine sold either by weight in ounces, referred to by terms such as "eight-ball" (one-eighth of an ounce) or "quarter" similarities between cocaine use and amphetamine use and "half" respectively. In the alternate, $20 smoking cocaine pieces of crack cocaine are aggregated in units of "fifty pack" and "hundred street names for cocaine pack", referring to the number of pieces. At this system of a down this cocaine makes me feel level, the wholesale price is approximately half the street washing cocaine sale price.
Crack cocaine was extremely popular in the mid- and late 1980s in a period known yacht cocaine as the Crack Epidemic, especially in inner cities, though its popularity 1 kilo of cocaine declined through the 1990s in the United States. There were major anti-drug campaigns launched in the U.S. to aciphex aciphex aciphex cocaine try and cull its popularity, the most popular being a series of ads barney the purple dinosaur and cocaine featuring the slogan "The Thrill Can Kill". 1 However, there bc canada cocaine laws has been an best cut cocaine increase in popularity within Canada in the recent years, where it has been estimated that the drug has become a cash cocaine blues multi-billion dollar 'industry'. changes , feelings after cocaine abstinence Due to its popularity, there are many different street names for crack cocaine.
Although consisting cocaine addictions of the same active drug as powder cocaine, crack cocaine in the United States is seen as a drug primarily by and cocaine addition cocaine bugs for the inner-city poor; the stereotypical "crack head" is a poor, urban, usually homeless cocaine bullet person of color. While insufflated powder cocaine has an associated glamour cocaine hair test attributed to its popularity among mostly middle and upper class whites (as well cocaine humor as musicians and entertainers), crack is perceived as a skid row drug of squalor and desperation. The cocaine in my brain U.S. federal trafficking penalties deal far more cocaine indictments in springfield illinois harshly towards crack when compared to powdered cocaine. Possession of five cocaine induced depression message boards grams of crack (or over 500 grams of powder) carries a minimum sentence cocaine induced depression stories of five years imprisonment.
Modes of administration
Coca leaves typically are mixed with an alkaline substance (such as lime) cocaine induced depression, thoughts , feelings, changes and chewed into cocaine induced depression,fear,and changes a wad that is retained in the mouth between gum and cheek and sucked of its juices. The cocaine leaf juices are absorbed slowly by the mucous cocaine measurements membrane of the inner cheek and by the gastro-intestinal cocaine metabolite tract when swallowed. Alternatively, coca leaves can be infused in liquid and consumed like tea. Ingesting cocaine metaline coca leaves generally is an inefficient means of administering cocaine. It should be cocaine potency remembered that the coca leaf is not actual cocaine, and is not a cocaine pringles drug of any kind. Because cocaine is hydrolyzed (rendered cocaine processing inactive) in the acidic stomach, it is not readily absorbed. Only when mixed with a highly alkaline substance (such as lime) cocaine recovery process can cocaine use and concerns it be absorbed into the bloodstream through the stomach. Absorption of orally administered cocaine is limited by two additional factors. cocaine video First, the drug is partly crack cocaine sentencing metabolized in the liver. Second, capillaries in the mouth and esophagus constrict after contact with the drug, reducing cut cocaine properly the surface area over which dillinger cocaine the drug can be absorbed.
Orally administered cocaine takes approximately 30 minutes drink cocaine to enter the bloodstream. Typically, only 30 percent of an oral dose is absorbed, although absorption has been shown to drug test cocaine reach 60 percent in controlled settings. Given the slow rate of absorption, maximum physiological and effect of cocaine addiction on infants psychotropic effects are errol washington benjamin cocaine attained approximately 60 minutes after cocaine is administered by ingestion. While the onset of these flushing cocaine from the system effects is slow, the effects are sustained for approximately 60 minutes after their peak is attained.
Contrary to popular belief, fmri scan of a cocaine addict both ingestion and insufflation how many grams is in a teener of cocaine result in approximately the same proportion of the drug being absorbed: 30 to how to cook crack cocaine 60 percent. G. Barnett, R. Hawks and how to crack cocaine R. Resnick, "Cocaine Pharmacokinetics in Humans," 3 Journal of Ethnopharmacology 353 (1981); Jones, supra note 19; Wilkinson et how to dry out cocaine al., Van Dyke et al., Compared to ingestion, the faster absorption of how to hide the smell of cocaine insufflated cocaine results in quicker attainment of maximum infants and siezures cocaine drug effects. Snorting cocaine produces maximum physiological effects within 40 minutes major causes for cocaine use and maximum psychotropic effects within 20 minutes, However a more realistic activation period is closer to 5 to 10 minutes, negative effects of cocaine on society which is similar to ingestion of penalty for cocaine cocaine. Physiological and psychotropic effects from nasally insufflated cocaine are sustained for approximately physiological effects after quitting cocaine 40 - 60 minutes after the peak effects are attained. Van Dyke, et al.
Mate de coca or rock cocaine coca-leaf tea is also a traditional method of consumption short term effects of cocaine and is often recommended to treat this cocaine makes me feel like im on this song altitude sickness. This method of consumption has been practiced for thousands of years by South American natives. One specific purpose of ancient coca toddler cocaine leaf consumption was to increase energy and reduce tom davis cocaine fatigue in messengers who made multi-day quests to other use cocaine settlements.
In 1986 an article in the Journal of the American Medical Association revealed using cocaine hepatitis c that health food stores were selling coca-leaf video of man high on cocaine tea as “Health Inca Tea.” While the packaging claimed it had been “decocainized,” no such process had taken weight and price of cocaine in the us place—they were selling a controlled substance off what is the smell of crack cocaine the shelves. The article stated that drinking two cups of the what pills have cocaine tea per day gave a mild stimulation, increased heart rate, and mood elevation, and what to expect after cocaine and alcohol abstinence the tea was essentially harmless. Despite this, the DEA seized several shipments in zz top cocaine Hawaii, Chicago, Illinois, Georgia, and several locations on the East Coast of the United States, and the product adlerian therapy and cocaine abuse was removed from the shelves.
Insufflation (known colloquially as “snorting," “sniffing," or "blowing") is the most anxiety disorders linked to cocaine use common method of ingestion of recreational powder cocaine in the Western world. Contrary avoid testing positive for cocaine to widespread belief, cocaine is not actually inhaled using babes snorting cocaine this method; rather the drug coats and is absorbed through the mucous membranes lining the sinuses. bipolar disorder and cocaine When insufflating cocaine, absorption through the nasal membranes is approximately 30-60 percent, with higher doses leading buying cocaine online to increased absorption efficiency. can nasal cocaine use cause meningitis Any material not directly absorbed through the mucous chocolate and baking powder and cocaine membranes is collected in mucus and swallowed (this "drip" is considered pleasant by some and unpleasant clendenin man arrested for cocaine by others). In a study of cocaine users, the average cocaine addict stories time taken to reach peak subjective effects was 14.6 minutes. Chronic use results in cocaine addiction stories ongoing rhinitis and necrosis of the nasal membranes. Many users report a burning sensation in the nares cocaine and biploar disorder (nostrils) after cocaine's anasthetic effects wear off. cocaine and procaine Any damage to the inside of the nose is because cocaine highly constricts blood cocaine beauty vessels— and therefore blood & oxygen/nutrient flow— to that area. If cocaine birth defects this restriction of adequate blood supply is bad enough and, especially prolonged enough, the tissue cocaine blue there can die.
Prior to insufflation, cocaine powder must be divided into very fine particles. cocaine blues mp3 Cocaine of high cocaine brazil purity breaks into fine dust very easily, except when it is moist (not cocaine bust well stored) and forms “chunks,” which reduce the efficiency of nasal absorption.
Rolled up banknotes (traditionally a high-denomination one as extra cocaine caffine new york status symbol), cocaine depression mental health statistics hollowed-out pens, cut straws, pointed ends of keys, and specialized spoons are often used to insufflate cocaine. Such devices are often cocaine depression questions referred to as "tooters" cocaine detox body detoxification detox 5 day rapid by users. The cocaine typically is poured onto a flat, hard surface (such as a cocaine detox body detoxification detox 7 day rapid mirror) and divided into "lines" (usually with a razor blade, credit card or driver's license card), which are cocaine detox body detoxification detox 7 day rapid drug then insufflated. The amount of cocaine in a line varies widely from cocaine drug person to person and occasion to occasion (the purity cocaine drug tests of the cocaine is also cocaine engergy drink a factor), but one line is generally considered to be a single dose cocaine eyes lyrics and is typically 35mg-100mg. However, as tolerance builds rapidly in the cocaine faq short-term (hours), many lines are often snorted to produce greater cocaine forum effects.
Drug injection provides the highest blood levels of drug in the shortest amount of time. Upon injection, cocaine reaches cocaine grinder the brain in a matter of seconds, and the exhilarating rush cocaine hangover cures that follows can be so intense that it induces some users cocaine in coca cola to vomit uncontrollably. In a cocaine in the us study of cocaine users, the average time taken to reach peak subjective effects was cocaine induced depression fear and anxiety 3.1 minutes. The euphoria passes quickly. Aside from the toxic effects of cocaine, there is cocaine jackson also danger of circulatory emboli from the insoluble substances cocaine kate that may be used to cut the drug. There is also a cocaine levels risk of serious infection associated with the use of contaminated needles.
An injected mixture of cocaine and heroin, known as cocaine meth “speedball” or “moonrock”, is a particularly popular and dangerous cocaine microwave combination, as the converse effects of the drugs actually complement each other, but may also cocaine ng/ml mask the symptoms of an overdose. It has been responsible for cocaine overdose signs numerous deaths, particularly in cocaine prices mexico and around Los Angeles, including celebrities such as John Belushi, Chris Farley, Layne Staley and River cocaine products Phoenix. Experimentally, cocaine injections can be delivered to animals such cocaine raps as fruit flies in order to study the cocaine rock crack how to mechanisms of cocaine addiction.
A woman smoking crack cocaine seeds from a glass pipe
- See also: crack cocaine above.
Smoking freebase or crack cocaine is most cocaine seizures by boat in europe often accomplished using a pipe made from a cocaine spoons small glass tube about one quarter-inch (about 6 mm) in diameter and on cocaine statistics the average, four inches long. These are sometimes called "stems", "horns", "blasters" and "straight shooters," readily available cocaine true cocaine blue in convenience stores or smoke cocaine urine tests shops. They will sometimes contain a small paper flower and are promoted as a romantic gift. Buyers usually cocaine withdrawals ask for a "rose" or a cocoa and cocaine "flower." An alternate method is to use a small length of con cocaine a radio antenna or similar metal tube. To avoid burning the user’s fingers and lips on the metal cook cocaine to crack pipe, a small piece crack cocaine additives of paper or cardboard (such as a piece torn from a matchbook cover) is wrapped around crack cocaine babies one end of the pipe and held in place with either a rubber band or a piece of adhesive crack cocaine ingredients tape. A popular crack cocaine pictures (usually pejorative) term for crack pipes is "glass dick."
A small piece (approximately one inch) of crack cocaine recovery heavy steel or copper scouring pad — often called a "brillo" or "chore", from different ways of using cocaine the scouring pads of the same name — is placed into one end of the tube easy crack cook cocaine and eight ball cocaine carefully packed down to approximately three-quarter inch. Prior to insertion, the "brillo" is burnt off, to remove any oily coatings encouragement for a cocaine addict that may be present. It then serves energy drink cocaine as a reduction base and flow modulator in which the "rock" can melt and boil to energy drink, cocaine vapor.
The "rock" is placed at enjoy cocaine the end of the pipe closest to the filter and the other end of the pipe is placed in the eric clapton, cocaine mouth. A flame from a cigarette lighter or handheld torch eric clapton: cocaine is then held under the rock. As the rock is heated, it melts and facts after stopping cocaine use burns away to vapor, which the user inhales as smoke. fear of life after cocaine abstinence The effects, felt almost immediately after smoking, are very fedx cocaine intense and do not last long — usually five to fifteen minutes. In a study of cocaine users, fentanyl and cocaine the freud and cocaine average time taken to reach peak subjective effects was 1.4 minutes. Most users will want more after this time, especially gram of cocaine frequent users. "Crack houses" depend on these cravings by providing users a place to smoke, and greece cocaine a ready supply of small bags heart and cocaine for sale.
A heavily used crackpipe tends to fracture at hendrix guitar tabs cocaine the end from overheating with the flame used to heat the crack as homemade cocaine the user attempts to inhale every bit of the drug on the metal wool filter. The end is often broken how can you tell if someone is using cocaine how to free-base cocaine further as the user "pushes" the pipe. "Pushing" is a technique used to partially recover crack that hardens on how to grow cocaine the inside wall of the pipe as the pipe cools. The user pushes how to help a crack cocaine addict the metal wool filter through the pipe from how to make crack from cocaine one end to the other to collect the build-up inside the pipe, which is a very pure and how to prepare crack cocaine for injection potent form of the base. The how to smoke cocaine ends of the pipe can be broken by the object used to how to use cocaine push the filter, frequently a small screwdriver or stiff piece i love cocaine of wire. The user will often remove the most jagged edges and continue jimi hendrix cocaine using the pipe until it becomes so short that it burns the lips and fingers. lawrence taylor and cocaine To continue using the pipe, the user will sometimes wrap a small piece lose of interest in life during cocaine abstinence of paper or cardboard around one end and hold it in place with a rubber band losing interest in life after quitting cocaine or adhesive tape. Of course, not all people who smoke crack cocaine will let it get that short, and will get a new or different pipe. The tell-tale signs of a used crack pipe are a glass tube with burn marks at one or both ends and a clump of metal wool inside. The language used to refer to the paraphernalia and practices of smoking cocaine vary tremendously across regions of the United States, as do the packaging methods utilized in the street level sale.
When smoked, cocaine is sometimes combined with other drugs, such as cannabis; often rolled into a joint or blunt. This combination is known as "primo", "chevy", "hype", "shake and bake",a "turbo" "SnowCaps", "B-151er", a "cocoapuff", a "dirty" a "woo", or "geeking." Crack smokers who are being drug tested may also make their "primo" with cigarette tobacco instead of cannabis, since a crack smoker can test clean within two to three days of use, if only urine (and not hair) is being tested.
Powder cocaine is sometimes smoked, but it is inefficient as the heat involved destroys much of the chemical. One way of smoking powder is to put a "bump" into the end of an unlit cigarette(a.k.a a 'jimmy'), smoking it in one go as the user lights the cigarette normally.
Cocaine can also be taken by oral methods. One method of achieving a cocaine high is to rub the powder along the gum line, which renders the gums and teeth numb: hence the colloquial name of "numbies" for this type of administration. This is commonly done with the small amounts of cocaine remaining on a surface after insufflation. Another oral method is to wrap up some cocaine in rolling paper and swallow it. This is called a "speed bomb".
Mechanism of action
The pharmacodynamics of cocaine are complex. One significiant effect of cocaine on the central nervous system is the blockage of the dopamine transporter protein (DAT), hence cocaine is called a dopamine reuptake inhibitor. Brain regions that are rich with dopaminergic neurons are the ventral tegmental area (VTA), and the substantia nigra (SN). The dopamine (DA) neurons of the VTA send axons to the nucleus accumbens (nAC)and the prefrontal cortex (PFC) and release DA presynaptically on the neurons in these regions. While the precise role of DA in the subjective experience of reward is controversial among neuroscientists, the release of DA in the nAC is widely considered to be responsible for cocaine's rewarding effects. This conclusion is largely based on laboratory data involving rats that are trained to self-administer cocaine intravenously (i.v.). If DA antagonists are infused directly into the nAC, well-trained rats self-administering cocaine will undergo extinction (i.e., initially increase responding only to stop completely) thereby indicating that cocaine is no longer reinforcing (i.e., rewarding) drug-seeking behavior.
A monoamine transmitter by a neuron for signal firing is normally recycled via the transporter to terminate the signal and to spare transmitter resources. The transporter binds the transmitter and pumps it out of the synaptic cleft back into the pre-synaptic neuron. There it is taken up into storage vesicles. Cocaine binds tightly at the DAT forming a complex that blocks the transporter's function, this also blocks the reuptake of the transmitter. Once released into the extracellular space (synaptic cleft) dopamine accumulates there, because the recycling mechanism is inhibited by the cocaine. This results in an enhanced and prolonged post-synaptic effect of dopaminergic signalling at dopamine receptors on the receiving neuron. Prolonged exposure to cocaine, as occurs with habitual use, leads to homeostatic dysregulation of normal (i.e., without cocaine) dopaminergic signalling via downregulation of D1 receptors and enhanced signal transduction. The decreased dopaminergic signalling after chronic cocaine use may contribute to depressive mood disorders and sensitize this important brain reward circuit to the reinforcing effects of cocaine (e.g., enhanced dopaminergic signalling only when cocaine is self-administered). This sensitization contributes to the intractable nature of addiction and relapse.
Cocaine is also a less potent blocker of the norepinephrine transporter (NET) and serotonin transporter (SERT). Cocaine also blocks sodium channels, thereby interfering with the propagation of action potentials; thus, like lignocaine and novocaine, it acts as a local anesthetic. The locomotor enhancing properties of cocaine may be attributable to its enhancement of dopaminergic transmission from the substantia nigra. Recent research points to an important role of circadian mechanisms  and clock genes  in behavioral actions of cocaine.
Because nicotine increases the levels of dopamine in the brain, many cocaine users find that consumption of tobacco products during cocaine use enhances the euphoria. This, however, may have undesirable consequences, such as uncontrollable chain smoking during cocaine use (even users who don't normally smoke cigarettes have been known to chain smoke when using cocaine), in addition to the detrimental health effects and the additional strain on the cardiovascular system caused by tobacco.
Metabolism and excretion
Cocaine is extensively metabolized, primarily in the liver, with only about 1% excreted unchanged in the urine. The metabolism is dominated by hydrolytic ester cleavage, so the eliminated metabolites consist mostly of benzoylecgonine, the major metabolite, and in lesser amounts ecgonine methyl ester and ecgonine.
If taken with alcohol, cocaine combines with the ethanol in the liver to form cocaethylene, which is both more euphorigenic and has higher cardiovascular toxicity than cocaine by itself.
Cocaine metabolites are detectable in urine for up to four days after cocaine is used. Benzoylecgonine can be detected in urine within four hours after cocaine inhalation and remains detectable in concentrations greater than 1000 ng/ml for as long as 48 hours. Detection in hair is possible in regular users until the sections of hair grown during use are cut or fall out.
Effects and health issues
Cocaine is a potent central nervous system stimulant. Its effects can last from 20 minutes to several hours, depending upon the dosage of cocaine taken, purity, and method of administration.
The initial signs of stimulation are hyperactivity, restlessness, increased blood pressure, increased heart rate and euphoria. The euphoria is sometimes followed by feelings of discomfort and depression and a craving to experience the drug again. Sexual interest and pleasure can be amplified. Side effects can include twitching, paranoia, and impotence, which usually increases with frequent usage.
With excessive dosage the drug can produce hallucinations, paranoid delusions, tachycardia, itching, and formication.
Overdose causes tachyarrhythmias and a marked elevation of blood pressure. These can be life-threatening, especially if the user has existing cardiac problems.
The LD50 of cocaine when administered to mice is 95.1 mg/kg. Toxicity results in seizures, followed by respiratory and circulatory depression of medullar origin. This may lead to death from respiratory failure, stroke, cerebral hemorrhage, or heart-failure. Cocaine is also highly pyrogenic, because the stimulation and increased muscular activity cause greater heat production. Heat loss is inhibited by the intense vasoconstriction. Cocaine-induced hyperthermia may cause muscle cell destruction and myoglobinuria resulting in renal failure. There is no specific antidote for cocaine overdose.
Cocaine's primary acute effect on brain chemistry is to raise the amount of dopamine and serotonin in the nucleus accumbens (the pleasure center in the brain); this effect ceases, due to metabolism of cocaine to inactive compounds and particularly due to the depletion of the transmitter resources (tachyphylaxis). This can be experienced acutely as feelings of depression, as a "crash" after the initial high. Further mechanisms occur in chronic cocaine use.
With chronic cocaine intake, brain cells functionally adapt (respond) to strong imbalances of transmitter levels in order to compensate extremes. So receptors disappear from or reappear on the cell surface, resulting more or less in an "off" or "working mode" respectively, or they change their susceptibility for binding partners (ligands) – mechanisms called down-/upregulation. Chronic cocaine use leads to a DAT upregulation, further contributing to depressed mood states. Finally, a loss of vesicular monoamine transporters, neurofilament proteins, and other morphological changes appear to indicate a long term damage of dopamine neurons.
All these effects contribute to the rise in an abuser's tolerance thus requiring a larger dosage to achieve the same effect. The lack of normal amounts of serotonin and dopamine in the brain is the cause of the dysphoria and depression felt after the initial high. The diagnostic criteria for cocaine withdrawal is characterized by a dysphoric mood, fatigue, unpleasant dreams, insomnia or hypersomnia, E.D., increased appetite, psychomotor retardation or agitation, and anxiety.
Cocaine abuse also has multiple physical health consequences. It is associated with a lifetime risk of heart attack that is seven times that of non-users. During the hour after cocaine is used, heart attack risk rises 24-fold.
Side effects from chronic smoking of cocaine include chest pain, lung trauma, shortness of breath, sore throat, hoarse voice, dyspnea, and an aching, flu-like syndrome. A common misconception is that the smoking of cocaine chemically breaks down tooth enamel and causes tooth decay. However, cocaine does often cause involuntary tooth grinding, known as bruxism, which can deteriorate tooth enamel and lead to gingivitis
Chronic intranasal usage can degrade the cartilage separating the nostrils (the septum nasi), leading eventually to its complete disappearance. Due to the absorption of the cocaine from cocaine hydrochloride, the remaining hydrochloride forms a dilute hydrochloric acid.
Cocaine may also greatly increase this risk of developing rare autoimmune or connective tissue diseases such as lupus, Goodpasture's disease, vasculitis, glomerulonephritis and other diseases. . It can also cause a wide array of kidney diseases and renal failure . While these conditions are normally found in chronic use they can also be caused by short term exposure in susceptible individuals.
There have been published studies reporting that cocaine causes changes in the frontal lobe of the brain. The full extent of possible brain deterioration from cocaine use is not known.
Cocaine as a local anesthetic
Cocaine was historically useful as a topical anesthetic in eye and nasal surgery, although it is now predominantly used for nasal and lacrimal duct surgery. The major disadvantages of this use are cocaine's intense vasoconstrictor activity and potential for cardiovascular toxicity. Cocaine has since been largely replaced in Western medicine by synthetic local anaesthetics such as benzocaine, proparacaine, and tetracaine though it remains available for use if specified. If vasoconstriction is desired for a procedure (as it reduces bleeding), the anesthetic is combined with a vasoconstrictor such as phenylephrine or epinephrine. In Australia it is currently prescribed for use as a local anesthetic for conditions such as mouth and lung ulcers. Some Australian ENT specialists occasionally use cocaine within the practice when performing procedures such as nasal cauterization. In this scenario dissolved cocaine is soaked into a ball of cotton wool, which is placed in the nostril for the 10-15 minutes immediately prior to the procedure, thus performing the dual role of both numbing the area to be cauterized and also vasoconstriction.
Bricks of cocaine, a form in which it is commonly transported.
Because of the extensive processing it undergoes during preparation and its highly addictive nature, cocaine is generally treated as a 'hard drug', with severe penalties for possession and trafficking. Demand remains high, and consequently black market cocaine is quite expensive. Unprocessed cocaine, such as coca leaves, is occasionally bought and sold, but this is exceedingly rare as it is much easier and more profitable to conceal and smuggle it in powdered form.
As of 1999, Colombia was the world's leading producer of cocaine. Three-quarters of the world's annual yield of cocaine was produced there, both from cocaine base imported from Peru (primarily the Huallaga Valley) and Bolivia, and from locally grown coca. There was a 28 percent increase from the amount of potentially harvestable coca plants which were grown in Colombia in 1998. This, combined with crop reductions in Bolivia and Peru, made Colombia the nation with the largest area of coca under cultivation. Coca grown for traditional purposes by indigenous communities, a use which is still present and is permitted by Colombian laws, only makes up a small fragment of total coca production, most of which is used for the illegal drug trade. Attempts to eradicate coca fields through the use of defoliants have devastated part of the farming economy in some coca growing regions of Colombia, and strains appear to have been developed that are more resistant or immune to their use. Whether these strains are natural mutations or the product of human tampering is unclear. These strains have also shown to be more potent than those previously grown, increasing profits for the drug cartels responsible for the exporting of cocaine. The cultivation of coca has become an attractive, and in some cases even necessary, economic decision on the part of many growers due to the combination of several factors, including the persistence of worldwide demand, the lack of other employment alternatives, the lower profitability of alternative crops in official crop substitution programs, the eradication-related damages to non-drug farms, and the spread of new strains of the coca plant.
Estimated Andean Region Coca Cultivation and Potential Pure Cocaine Production, 2000–2004.
|Net Cultivation (km²)
|Potential Pure Cocaine Production (tonnes)
Trafficking and distribution
Organized criminal gangs operating on a large scale dominate the cocaine trade. Most cocaine is grown and processed in South America, particularly in Colombia and Peru, and smuggled into the United States and Europe, where it is sold at huge markups.
Cocaine shipments from South America transported through Mexico or Central America are generally moved over land or by air to staging sites in northern Mexico. The cocaine is then broken down into smaller loads for smuggling across the U.S.–Mexico border. The primary cocaine importation points in the United States are in Arizona, southern California, southern Florida, and Texas. Typically, land vehicles are driven across the U.S.-Mexico border.
Cocaine is also carried in small, concealed, kilogram quantities across the border by couriers known as “mules” (or “burros”), who cross a border either legally, e.g. through a port or airport, or illegally through undesignated points along the border. The drugs may be strapped to the waist or legs or hidden in bags, or hidden in the body. If the mule gets through without being caught, the gangs will reap most of the profits. If he or she is caught however, gangs will sever all links and the mule will usually stand trial for trafficking by him- or herself.
Cocaine traffickers from Colombia, and recently Mexico, have also established a labyrinth of smuggling routes throughout the Caribbean, the Bahama Island chain, and South Florida. They often hire traffickers from Mexico or the Dominican Republic to transport the drug. The traffickers use a variety of smuggling techniques to transfer their drug to U.S. markets. These include airdrops of 500–700 kg in the Bahama Islands or off the coast of Puerto Rico, mid-ocean boat-to-boat transfers of 500–2,000 kg, and the commercial shipment of tonnes of cocaine through the port of Miami.
Bulk cargo ships are also used to smuggle cocaine to staging sites in the western Caribbean–Gulf of Mexico area. These vessels are typically 150–250 foot (50–80 m) coastal freighters that carry an average cocaine load of approximately 2.5 tonnes. Commercial fishing vessels are also used for smuggling operations. In areas with a high volume of recreational traffic, smugglers use the same types of vessels, such as go-fast boats, as those used by the local populations.
Traffickers have also started using a method whereby a substance such as iron thiocyanate, a mixture of cobalt and ferric chloride, or a mixture of charcoal and iron filings is added to cocaine hydrochloride to produce “black cocaine.” The cocaine in this substance is not detected by standard chemical tests such as the Becton Dickinson test kit. The substance was first identified after a seizure in March 1998 in Germany, which was then tracked back to discover 250 lb of black cocaine ready for transport at Bogotá’s airport.
Cocaine addiction is the excessive intake of cocaine, and can result in physiological damage, lethargy, depression, or a potentially fatal overdose. The immediate craving to use more cocaine is strong and very common, because euphoric effects usually subside in most users within an hour of the last dosage, leading to serial cocaine readministrations, and prolonged, multi-dose binge use in those who are addicted. When administration stops after binge use, it is followed by a "crash", the onset of severely dysphoric mood with escalating exhaustion until sleep is achieved. Resumption of use may occur upon awakening or may not occur for several days, but the intense euphoria such use can, as it has in many users, produce intense craving and develop rather quickly into addiction. The risk of becoming cocaine-dependent within 2 years of first use(recent-onset) is 5-6%; after 10 years, it's 15-16%. These are the aggregate rates for all types of use considered, i.e., smoking, snorting, injecting. Among recent-onset users, the relative rates are higher for smoking (3.4 times) and much higher for injecting (31 times). They also vary, based on other characteristics, such as gender: among recent-onset users, females are 3.3 times more likely to become addicted, compared to males; age: among recent-onset users, those who started using at ages 12 or 13 were 4 times as likely to become addicted, compared to those who started between ages 18 and 20; and race: among recent-onset users, non-Hispanic Blacks are 7 times as likely to become addicted, compared to non-Hispanic Whites. Many habitual abusers develop a transient manic-like condition similar to amphetamine psychosis and schizophrenia, whose symptoms include aggression, severe paranoia, and tactile hallucinations (including the feeling of insects under the skin, or "coke bugs") during binges.
Cocaine has positive reinforcement effects, which refers to the effect that certain stimuli have on behavior. Good feelings become associated with the drug, causing a frequent user to take the drug as a response to bad news or mild depression. This activation strengthens the response that was just made. If the drug was taken by a fast acting route such as injection or inhalation, the response will be the act of taking more cocaine, so the response will be reinforced. Powder cocaine, being a club drug is mostly consumed in the evening and night hours. Because cocaine is a stimulant, a user will often drink large amounts of alcohol during and after usage or smoke cannabis to dull "crash" effects and hasten slumber. Benzodiazepines (e.g., xanax, rohypnol) are also used for this purpose. Other drugs such as heroin and various pharmaceuticals are often used to amplify reinforcement or to minimize such negative effects, further increasing addiction potential and harmfulness.
It is speculated that cocaine's addictive properties stem partially from its DAT-blocking effects (in particular, increasing the dopaminergic transmission from ventral tegmental area neurons). However, a study has shown that mice with no dopamine transporters still exhibit the rewarding effects of cocaine administration. Later work demonstrated that a combined DAT/SERT knockout eliminated the rewarding effects. The rewarding effects of cocaine are influenced by circadian rhythms, possibly by involving a set of genes termed "clock genes". However, chronic cocaine addiction is not solely due to cocaine reward. Chronic repeated use is needed to produce cocaine-induced changes in brain reward centers and consequent chronic dysphoria (described above under "Effects and Health Issues - Chronic"). Dysphoria magnifies craving for cocaine because cocaine reward rapidly, albeit transiently, improves mood. This contributes to continued use and a self-perpetuating, worsening condition, since those addicted usually cannot appreciate that long-term effects are opposite those occurring immediately after use.
Cognitive Behavioral Therapy (CBT) shows promising results. One or more cocaine vaccines exist or are on trial that will stop desirable effects from the drug. The National Institutes of Health of an unspecified country is researching modafinil, a narcolepsy drug and mild stimulant, as a potential cocaine treatment. Twelve-step programs such as Cocaine Anonymous (modeled on Alcoholics Anonymous) are claimed by many cocaine addicts to be helpful in achieving long-term abstinance. These spiritual programs have no statistically-measurable effect as Alcoholics Anonymous does not release any quantifiable measure of its success rates. There are, however, many recovering addicts who claim this program has aided them.
Positron Emission Tomography scans showing the average level of dopamine receptors in six primates' brains. Red is high- and blue is low-concentration of dopamine receptors. The higher the level of dopamine, the fewer receptors there will be.
Studies have shown that gamma vinyl-gamma-aminobutyric acid (gamma vinyl-GABA, or GVG), a drug normally used to treat epilepsy, blocks cocaine's action in the brains of primates. GVG increases the amount of the neurotransmitter GABA in the brain and reduces the level of dopamine in the region of the brain that is thought to be involved in addiction. In January 2005 the U.S. Food and Drug Administration gave permission for a Phase I clinical trial of GVG for the treatment of addiction. Another drug currently tested for anti-addictive properties is the cannabinoid antagonist rimonabant.
GBR 12909 (Vanoxerine) is a selective dopamine uptake inhibitor. Because of this, it reduces cocaine's effect on the brain, and may help to treat cocaine addiction. Studies have shown that GBR, when given to primates, suppresses cocaine self-administration.
Venlafaxine (Effexor), although not a dopamine re-uptake inhibitor, is a serotonin-norepinephrine reuptake inhibitor that has been successfully used to combat the depression caused by cocaine withdrawal and to a lesser extent, the addiction associated with the drug itself. Venlafaxine has been shown to have significant withdrawal problems itself, and can lead to lifetime use due to these withdrawal effects. A statisically significant number of people prescribed Effexor have committed suicide (2 attempts per 1000 patients, vs 1.56 suicides per 1,000 untreated depressives).
Coca herbal tea has been used for the treatment of cocaine dependence. In one study, coca tea was used—in addition to counseling—to treat 23 addicted coca-paste smokers in Lima, Peru. Relapses fell from an average of 4.35 times per month before treatment with coca tea to 1.22 during the treatment. Abstinence length increased from an average of 32 days prior to treatment to 217.2 days during treatment. These results suggest that coca tea is an effective method for preventing relapse during treatment for cocaine addiction.
The production, the distribution and the sale of cocaine products is restricted (and illegal in most contexts) in most countries. Since 1914, when The Harrison Narcotics Tax Act passed in the U.S., cocaine has been considered a ‘hard drug.' In Colombia, the indigenous population is allowed to grow coca for traditional reasons.
All other coca is considered part of the illegal black market. In parts of Africa, it is a crime to be in possession of cocaine or even be seen with it. In South America, cultivation of coca is allowed only with special permission; however, it is a crime to posses processed cocaine. Some parts of Europe and Australia allow processed cocaine for medicinal uses only. Also, in some parts of the Middle East and Asia, being in possession of cocaine can be punishable by death. 
In the United States
Though by the late 1800s many popular and significant figures of American society began to openly admit cocaine abuse and binges, the dangers of use were becoming rapidly apparent. There rose public outcry against the narcotic, and its use was quickly demonized. The immigrant and minority communities were blamed, coaxed by racist sentiments. Crime in the inner city increased.
During the 1960s cocaine had become mainstream again, yet it was still illegal. Prices of cocaine began to rise, and those of the lower class could no longer afford their addiction. Cocaine has become the second most popular illegal recreational drug in the U.S. Cocaine is generally used by privileged middle to upper class communities. It is also popular amongst college students, not just to aide in studying, but also as a party drug. Its users span over different ages, races, and professions.
The National Household Survey on Drug Abuse (NHSDA) reported in 1999 that cocaine was used by 3.7 million Americans, or 1.7 percent of the household population age 12 and older. Estimates of the current number of those who use cocaine regularly (at least once per month) vary, but 1.5 million is a widely accepted figure within the research community.
Although cocaine use had not significantly changed over the six years prior to 1999, the number of first-time users went up from 574,000 in 1991, to 934,000 in 1998 — an increase of 63%. While these numbers indicated that cocaine is still widely present in the United States, cocaine use was significantly less prevalent than it was during the early 1980s. Cocaine use peaked in 1982 when 10.4 million Americans (5.6 percent of the population) reportedly used the drug.
Usage among youth
The 1999 Monitoring the Future (MTF) survey found the proportion of American students reporting use of powder cocaine rose during the 1990s. In 1991, 2.3 percent of eighth-graders stated that they had used cocaine in their lifetime. This figure rose to 4.7 percent in 1999. For the older grades, increases began in 1992 and continued through the beginning of 1999. Between those years, lifetime use of cocaine went from 3.3 percent to 7.7 percent for tenth-graders and from 6.1 percent to 9.8 percent for twelfth-graders. Lifetime use of crack cocaine, according to MTF, also increased among eighth-, tenth-, and twelfth-graders, from an average of 2 percent in 1991 to 3.9 percent in 1999.
Perceived risk and disapproval of cocaine and crack use both decreased during the 1990s at all three grade levels. The 1999 NHSDA found the highest rate of monthly cocaine use was for those aged 18–25 at 1.7 percent, an increase from 1.2 percent in 1997. Rates declined between 1996 and 1998 for ages 26–34, while rates slightly increased for the 12–17 and 35+ age groups. Studies also show people are experimenting with cocaine at younger ages. NHSDA found a steady decline in the mean age of first use from 23.6 years in 1992 to 20.6 years in 1998.
Cocaine is readily available in all major U.S. metropolitan areas. According to the Summer 1998 Pulse Check, published by the U.S. Office of National Drug Control Policy, cocaine use had stabilized across the country, with a few increases reported in San Diego, Bridgeport, Miami, and Boston. In the West, cocaine usage was lower, which was thought to be because some users were switching to methamphetamine, which was cheaper and provides a longer-lasting high. Numbers of cocaine users are still very large, with a concentration among city-dwelling youth.
Cocaine is typically sold to users by the gram ($40-$80US) or eight ball (3.5 grams, or roughly 1/8th oz; hence the term "eight ball") ($125-$250). Quality and price can vary dramatically depending on demand and supply.
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- Coca eradication
- Crack baby
- Crack Epidemic
- Drug addiction
- Drug injection
- Drugs and prostitution
- Ecgonine benzoate
- List of celebrity cocaine addicts
- Methylecgonine cinnamate
- Slang names for Cocaine
- Psychoactive drug
- (-)-2-ß-Carbomethoxy-3-ß-(4-fluorophenyl)tropane naphthalenedisulfonate (CFT, WIN-35,428)
- Cocaine: an unauthorized biography by Dominic Streatfeild
- Über Coca by Sigmund Freud
- History of Coca. The Divine Plant of the Incas" by W. Golden Mortimer, M.D. 576 pp. And/Or Press San Francisco, 1974. No ISBN.
- The Triumph of Surgery by Jürgen Thorwald - Ch. 6 - The second battle against Pain (The early use of cocaine solution in eye surgery)
- Snowblind by Robert Sabbag
- The Man Who Made It Snow by Max Mermelstein. ISBN 0-671-70312-9
- Celerino III Castillo & Dave Harmon (1994). Powderburns: Cocaine, Contras & the Drug War, Sundial. ISBN 0-88962-578-6 (paperback) ISBN 0-8095-4855-0 (hardcover; Borgo Pr; 3rd ed.; 1995).
- Alexander Cockburn & Jeffrey St. Clair (1999). Whiteout: The CIA, Drugs and the Press, Verso. ISBN 1-85984-139-2 (cloth), ISBN 1-85984-258-5 (paperback). Cites 116 books.
- Frederick P. Hitz (1999). Obscuring Propriety: The CIA and Drugs, International Journal of Intelligence and Counterintelligence, 12(4): 448-462 DOI:10.1080/088506099304990
- Robert Parry (1999). Lost History: Contras, Cocaine, the Press & “Project Truth”, Media Consortium. ISBN 1-893517-00-4.
- Richard Smart (Hard Cover 1985). The Snow Papers The Atlantic Monthly Press ISBN 0-87113-030-0
- Peter Dale Scott & Jonathan Marshall (1991). Cocaine Politics: Drugs, Armies, and the CIA in Central America, University of California Press. ISBN 0-520-21449-8 (paperback, 1998 reprint), ISBN 0-520-07312-6 (hardcover, 1991), ISBN 0-520-07781-4 (paperback, 1992 reprint).
- Gary Webb(1998). Dark Alliance: The CIA, the Contras, and the Crack Cocaine Explosion, Seven Stories Press. ISBN 1-888363-68-1 (hardcover, 1998), ISBN 1-888363-93-2 (paperback, 1999).
- Philippe Bourgois In Search of Respect: Selling Crack in El Barrio. New York: Cambridge University Press. 2003. Second Updated Edition.
- Otto Snow THC & Tropacocaine ISBN 0-9663128-5-6 (paperback 2004)
- David Lee Cocaine Handbook ISBN 0-915904-56-X (paperback 1981)
- Adam Gottlieb Cocaine Tester's Handbook ASIN B0007C137A (paperback 1975)
- Adam Gottlieb Pleasures of Cocaine: If You Enjoy: This Book May Save Your Life ISBN 0-914171-81-X (paperback 1996)
- Carol Saline Doctor Snow: How the FBI Nailed a Ivy League Coke King ISBN 0-453-00593-4 (HardCover 1986)
- Mark Bowden Doctor Dealer: The Rise & Fall Of An All American Boy and his Multi-Million Dollar Cocaine Empire ISBN 0-446-51382-2 (HardCover 1987)
Look up Cocaine in
Wiktionary, the free dictionary.
- Cocaine Addictions
- Self-test — from Cocaine Addicts Anonymous
- Cocaine User Helping Hand — Internet Portal dedicated to help crack- and cocaine-addicted people. Contains wide variety of information on drug abuse, available treatment, and recovery issues.
- Good Drugs Guide
- The Erowid Cocaine Vault
- Urban Legends Reference Pages: Cokelore (Cocaine-Cola) — information about cocaine in Coke
- Addictive properties
- The Mystery of the Coca Plant that Wouldn't Die - Wired Magazine
- Shared Responsibility — Information about European cocaine use and drug trafficking in Colombia.
- Cocaine content of plants
- Cocaine.org — Information guide on Cocaine and its history, use/abuse, etc.
- Cocaine Financial Market Information from Havocscope
- Cocaine - The History and the Risks at h2g2
- Link page to external chemical sources.
Adrafinil, Armodafinil, Caffeine, Modafinil, Nicotine
|Sympathomimetic amines (R01, A08, and others)
Amphetamine, Benzylpiperazine, Cathinone, CFT, Chlorphentermine, Clobenzorex, Cocaine, Cyclopentamine, Diethylpropion, Ephedrine, Fenfluramine, Mazindol, 4-Methyl-aminorex, Methylone, Methylphenidate, Pemoline, Phendimetrazine, Phenmetrazine, Phentermine, Phenylephrine, Propylhexedrine, Pseudoephedrine, Sibutramine, Synephrine
|See also amphetamines
Categories: Articles with unsourced statements | Limited geographic scope | Alkaloids | Benzoates | Carboxylate esters | Class A drugs | Dopamine reuptake inhibitors | Local anesthetics | Quechua loanwords | Schedule II controlled substances | Stimulants | Sympathomimetic amines